Cevimeline hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的 M1 选择性毒蕈碱激动剂。

A potent M1-selective muscarinic agonist; decreases the K+-evoked [3H]ACh release from hippocampal synaptosomes and increases the K+-evoked [3H]DA release from striatal synaptosomes; attenuates cognitive dysfunctions in AF64A-treated rats with low toxicity.

In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration.

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg. Animal Model:Male Wistar rats (8-week-old) injected with angiotensin-IIDosage:0.008 mg/kg, 0.016 mg/kg Administration:Intraperitoneal injection Result:Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.

AF-102B hydrochloride | SNI-2011 hydrochloride

GPCR/G Protein

mAChR

mAChR

Other Indications

Other Disease

107220-28-0

235.774

C10H18ClNOS

>98% (HPLC)

10 mM in DMSO

C[C@@H](SC1)O[C@@]21CN3CCC2CC3.[H]Cl

Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, hydrochloride (1:1), (2'R,3R)-rel-

(-20℃)

With Ice Pack

≥ 2 years